Endocrine Abstracts

Poorly differentiated thyroid cancers are associated with variable types of p53 function derangements and bad prognosis due to the lack of effective treatments. SP600125 is a widely used JNK-inhibitor which recently showed anticancer properties in a p53 related way. Here, we tested the effect of SP600125 on four different thyroid cancer cell lines derived from PDTCs and ATCs with different p53 status.We analyzed the effects on cellular replication and ap...